Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. 23571587 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. 23296339 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. 10799751 2000
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. 19605830 2009
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. 23060451 2012
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians. 27260402 2016
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis. 22381401 2012
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. 9343467 1997
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 AlteredExpression disease BEFREE Taken together, we propose that the expression of APP-swe modulates global gene expression directed to AD pathogenesis. 21034535 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 AlteredExpression disease BEFREE These include the possibilities that mice are incapable of developing AD for reasons dependent on their APP sequence; and that appropriate regulation of APP gene is required for pathology to develop. 8117426 1993
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 AlteredExpression disease BEFREE We analyzed genome-wide interplay between promoter CpG DNA methylation and gene expression in an APP-sw-expressing AD model cell line. 22001921 2011
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 AlteredExpression disease BEFREE We have previously reported a significant association between early-onset Alzheimer's disease (EOAD) and an allele in the promoter of presenilin 1 (PSEN1) significantly decreasing PSEN1 expression in vitro. 11757955 2001
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2 		0.400 AlteredExpression disease BEFREE Moreover, the expression of AD-related Aquaporin 1 and presenilin 2 expression was regulated by APP-swe. 21034535 2010
Entrez Id: 358
Gene Symbol: AQP1
AQP1 		0.010 AlteredExpression disease BEFREE Moreover, the expression of AD-related Aquaporin 1 and presenilin 2 expression was regulated by APP-swe. 21034535 2010
Entrez Id: 84182
Gene Symbol: MINDY4
MINDY4 		0.010 AlteredExpression disease BEFREE Moreover, the expression of AD-related Aquaporin 1 and presenilin 2 expression was regulated by APP-swe. 21034535 2010
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3 		0.010 AlteredExpression disease BEFREE We observed decreased IGFBP3 expression in the H4-sw cell line as well as the hippocampus of AD model transgenic mice. 24964199 2014
Entrez Id: 4137
Gene Symbol: MAPT
MAPT 		0.350 PosttranslationalModification disease BEFREE We measured MAPT promoter methylation in a brain tissue cohort of early-onset Alzheimer's disease (EOAD) with defined causative mutations in the PSEN1 gene (Normal = 10, PSEN1 AD = 10), and idiopathic late-onset Alzheimer's disease (Normal = 12, LOAD = 12). 26159201 2015
Entrez Id: 1471
Gene Symbol: CST3
CST3 		0.310 Therapeutic disease CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785 2007
Entrez Id: 1471
Gene Symbol: CST3
CST3 		0.310 Therapeutic disease CTD_human Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. 18026100 2007
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Therapeutic disease CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255 2010
Entrez Id: 1392
Gene Symbol: CRH
CRH 		0.300 Therapeutic disease CTD_human Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. 7477348 1995
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease BEFREE Dominant missense mutations in the amyloid β (Aβ) precursor protein (APP) gene have been implicated in early onset Alzheimer disease. 27422356 2016
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease BEFREE Missense mutations in the genes coding for APP and for the polytopic membrane proteins presenilin (PS) 1 and PS2 have been linked to familial forms of early-onset Alzheimer's disease. 10026204 1999
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients. 27023435 2017
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease. 16325427 2006